Stabilization of the Intermediate in Frameshift Mutation

Overview

Journal Mutat Res

Publisher Elsevier

Specialty Genetics

Date 1999 Feb 25

PMID 10029680

Citations 16

Authors

D Sagher

A Hsu

B Strauss

Affiliations

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Abstract

A mismatch repair, proofreading deficient mutant of Escherichia coli lost a C from a C8 run at a rate 10 times higher than the loss of A from an A8 sequence in the same double mutant. This greater frameshift instability of a homopolymeric run of C's may be due to stabilization of a stacked intermediate. Gain of a (CA) unit in a similarly constructed (CA)15 sequence occurred at a rate about 1/3 that previously reported for a (CA)14 construct losing a (CA) repeat unit.

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