Features of the Immune Response to DNA in Mice. I. Genetic Control

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1976 Oct 1

PMID 1000882

Citations 2

Authors

G J Fournie

P H Lambert

P A MIESCHER

Affiliations

Soon will be listed here.

Abstract

The genetic control of the immune response to DNA was studied in various strains of mice F1 hybrids and corresponding back-crosses immunized with single stranded DNA complexed to methylated bovine serum albumin. Anti-DNA antibody response was measured by radioimmuno-logical technique. High responder, low responder, and intermediate responder strains were found and the ability to respond to DNA was characterized as a dominant genetic trait which is not linked to the major locus of histocompatibility. Studies in back-crosses suggested that this immune response is under multigenic control. High responder mice produce both anti-double stranded DNA and anti-single stranded DNA 7S and 19S antibodies, while low responder mice produce mainly anti-single stranded DNA 19S antibodies.

Citing Articles

The mouse immune response to the double stranded polyribonucleotide complex poly(G) . poly(C).

Gaffiero G, Robin P, NAHON E Clin Exp Immunol. 1984; 55(2):264-72.

PMID: 6697564 PMC: 1535814.

Evaluation of the simultaneous estimation of anti-dsDNA and anti-ssDNA antibodies for clinical purposes.

Lange A Clin Exp Immunol. 1978; 31(3):472-81.

PMID: 306905 PMC: 1541258.

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